I guess I will put my two cents in.
The DC-3 wing attachment design was very typical not only of that time period but was used all the way up to present day. The primary intent of the design was to facilitate switching wings out. Other aircraft that come to mind: Curtiss C-46, T-6 Texan, P2V, C-130, etc. Many other more modern aircraft used similar joints at other locations in the wing, for example 707 uses this type of joint at the WS733 production break.
As for being a safe, as with anything, if treated properly it will function properly. DC-3 was designed in an early period where we barely understood fatigue. This doesnt mean douglas engineers didnt know what they were doing. I have see the wing joint tests where all bolts were actually instrumented so they knew exactly what load was being transferred. However, in those days OEMs were not required to develop inspection programs, that was the responsibility of the operator. So, I believe the earliest AD on the DC-3 was issued in 1939 specifically for this joint because it was not being inspected. Also, there was no mandatory torque requirement on the bolts.
As far as I know, there are three documented wing fatigue failures of the DC-3 and I have copies of the lab reports for two of them. If interested, back in 2017 at the airworthiness assurance conference I presented a paper which details one of the accidents, should be able to located it on the web, its entitled Airframe Structural Fatigue - Past, Present and Future. Anyways, I can tell you the primary culprit was lack of proper inspection. The inspections missed the crack and therefore the wing failed. Similarly in 2005 a T-6 texan crashed in florida from a wing failure of the wing joint. Again, lack of inspection. Note both the DC-3 and the T-6 had been full scale fatigue tested but prior to rules requiring DTA and ICAs. I have seen these tests and they predicted the in-service cracking. Today the DC-3 has a SSID with an FAA AD on it which mandates inspections. T-6 and other ex-military aircraft typically do not.
Anyways, this type of joint can be made to work and last if properly taken care of and respected. Unfortunately, these joints get worked pretty hard and many operators incorporate several repairs, service bulletins and/or major modifications which make it difficult to inspect and also reduce the fatigue life. They dont realize that adding major straps for static strength can have a huge impact on the fatigue life of this type of joint. Then, the design is blamed for not being safe when in fact it is the lack of proper attention to detail. In my experience, very few perform thorough evaluations on these old birds and rarely revise the inspection procedures.