1) The best of two phase flow calculation still always 20% error from the real situation in specified operation range. Then if you have so wide operate envelop error could be 40-60%..
2) Many formular is good only for horizontal pipe not vertical pipe
3) Liquid/Gas ratio & its densidty in each pipe section will change when temperature/pressure change, so if Pi of each section change over 15%, you will get the mess, so try to make section more detail
4) always check /calculate new thermodynamic to create the correct fluid property
5)All commercial software has its own defualt, we must put correlated factor after calculation.
6) slug management require proper flow assurance full scope review a long the field life ( steady,dynamic,corrosion management,etc)