I agree with stenger. I design houses in Colorado and most of them always have a 18ft-20ft wall in the great room with large windows. I have found using LVL or LSL studs is the best solution to prevent deflections, reduce amount of lumber, and to provide a nice straight piece of material. I don't know how musg framing experience you have, but I hate trying to find a 20ft long 2x8 thats worth using. And yes you will need something more than just a few nails per code minimum at the top and botom plates. From your 80plf x 20ft/2 gives you 800lbs at each end. I usually use a Simpson A35 or similiar.
Also, are you using the component and cladding pressure? You should be. Typically, I have to design for 110mph exposure C (3 sec gust, IRC) which depending on geometry and building height usually gives me close to 30psf wind load. I hope this helps.