You might have an issue with bronze guides being considerably softer than cast iron and thus wearing faster.
They're used extensively on race engines because, in spite of their poor wear characteristics, they conduct heat away from the valve stem much better than do iron guides. Race engines are torn-down frequently, so high wear rates are acceptable.
That's where the beryllium-copper guides really shine: they have a higher thermal conductivity than bronze alloys, and a hardness equivalent to that of cast iron.
It requires different machining techniques, but these are well-understood, and I'm not sure that machining the stuff releases any "free" beryllium, so the health hazards are minimal - at least, I'm still alive, having done it off and on since 1975.
- R