The 15NiCuMoNb5 is similar to a P-No 3 base material, low alloy steel. The A 217 C5 is a casting, under ASTM A 217 specification and contains 5% Cr-0.5% Mo. Since this is a dissimilar metal weld, I would use a 90xx B3 electrode composition for filler metal. Use the preheat requirement for C5 (being the higher alloy).
For PWHT, since this is a dissimilar metal weld, I would butter the weld prep surface of the C5 material using 90xx B3 weld metal, PWHT the C5. Complete the final weld to the 15NiCuMoNb5 using 90xx B3 and PWHT following the PWHT requirements for this material.