Assumption propylene glycol antifreeze in water, in worst case, water leakage of cooling coil will make it through air to contact with oral pharmaceutical product. That’s the reason why the 1 degree C water without any antifreeze I want to design. Is it possible to use suitable component in piping selection and well insulation to prevent them from condensation and freezing in practice? Or, it is NOT possible for “the 1 degree C water without any antifreeze design” in practice.