Use a pressure/vacuum switch. Pipe the threaded connection to the process.
Wire the switch output to drive whatever you're thinking is going to be the alarm.
United Electric model H100-218 uses wetted brass/bronze sensor. No scale for adjusting the trip point.
H400-S126B uses 316SS wetted sensor, has an scale for adjusting the trip point.
Or you can use a gauge pressure/vacuum transmitter feeding an analog signal to an indicator with alarm relays or an alarm module.
Avoid the distributor who mistakenly tells you that you need an 'absolute' pressure anything. When you use terms like 27"Hg, then your vacuum is gauge pressure vacuum, referenced to atmosphere, not absolute pressure, referenced to absolute zero.