Since a 90 degree V2 can have perfect primary and secondary balance, you can basically stack them end to end to get bigger engines. You just need a big flywheel and a good damper to deal with the uneven firing order in some combinations. One remaining problem is that they're typically very wide.
... which is a good reason to make a V12 with a 60 degree angle; so it will more easily fit in the boat or truck or whatever. Even firing order is just a bonus.
ISTR that DDC/MTU/Tognum 2000 and 4000 series and similarly sized Caterpillar V engines all use a 90 degree V angle.
One reason for using the same V angle in a family of engines is that the automated machines used to bore the cylinders, deck the block, etc., are very expensive, but it's relatively simple to make one machining line handle different numbers of cylinder pairs, just by shutting off unused spindles, whereas changing the V angle requires a major structural change to the machine tools.
Mike Halloran
Pembroke Pines, FL, USA