abusementpark - the commentary in ASCE 7 does speak of multiple "layers" but setting aside the code for a second and thinking clearly of what wind actually "does" to a surface, the variation of wind across small areas provides a higher chance of peak loads for any kind of structural element (screw, girt, cladding, column, footing) with small areas. This is not a code thing or a layer thing. It is simply common sense and has been stated in numerous articles and publications.
The commentary is attempting to offer users a feel for elements which may receive load from multiple connections and "layers".
If you have a vertical column and footing that support only 100 s.f., I would use C&C wind load (roof uplift) on that column and footing, despite the fact that the column receives the wind load through roofing, insulation boards, screws attaching the boards, metal deck, joists, beams, bolts connecting beams, etc.
These layers do not PHYSICALLY change anything about what sort of wind pressure arrives at the top of the column.
For an element that is part of a MWFRS, you would design the brace system for MWFRS loads, AND, if the area on the brace is low, I would also design check for C&C as well. These are not mutually exclusive necessarily.