Phil, At first i thought i didn't need a cooler after the turbo but once we pressed on and increased boost it became apparent that although the system didn't suffer too much, the heat of the turbo charge air was getting high enough to cause the blower some issues in terms of thermal expansion. Eaton specify 50c as the maximum 'safe' intake temp for the HTV, not sure what it would be on the M45 unit. The other thing to consider is the higher the intake temp to the blower, the higher the outlet temp will be so the intercooler you have will need to be bigger to take more heat out before the throttle bodies. What I found through the development is the colder you can get the inlet to the blower, the denser the air being multiplied will be which is beneficial for power production everywhere in the rev range. Since your intake temp is up 20c, i'd be looking at a way - any way possible, to install a chargecooler after the turbo. This will benefit your setup in a few ways - safer for the blower, denser charge and feed your intercooler with cooler charge which in turn will lower your inlet temps and allowing more ignition advance. There's always a trade-off with cooling but generally the cooler you can get your charge into both the blower and the engine the better.
With throttle bodies, I assume you have some kind of bypass around the blower, or a pressure dump to unload the blower when the throttle butterflies are at low openings, such as cruise?
Over the winter i removed my water/air chargecooler system, all 40Kg of it and built a bespoke intercooler which gets it's air from the front of the car. It was back on the dyno on Saturday and we are seeing no more than 24c into the blower with an ambient temp of 16c on the day. This allowed us to see the same 850hp but at 2.5bar boost instead of the 2.75bar we needed last year. This is mostly due to the lower charge temp into the blower. Water/meth injection in my mind complicates things, it's always better to cool the charge with intercoolers if possible but if setup right, injecting water is also going to benefit the engine. There's a fine line in getting it right so it's problem free. Water will tend to condense on the inside of the intercooler core if not metered properly.
For your head gasket, it may be worth considering wire-ringing the heads. We have done this to our engine which has improved reliability but until you have checked the evidence from your failed gasket it's only speculation as to whether you need to go to that extreme.