Like asixth says, you probably need more than one model to design the building. I typically look at cracked columns with all shear going into my wall and a model with column stiffness so that you don't under-design your slab-column joint. Granted that when the slab column joint cracks, it won't see any more moment , but you will still be left with an ugly crack. Not to mention that the unbalanced moments at the column can affect your punching shear strength which is often the controlling parameter in flat slab design.
For spandrel beams, I have designed beams framing into the spandrel beam as pinned at the spandrel beam (provide more positive moment reinforcement) and design the spandrel beam for threshold torsion (to control torsional cracking). A spandrel beam is also a case of compatibility torsion if you have torsional moment redistribution. As asixth said, torsional stiffness degenerates rapidly with cracking.
There was a paper published by Collins regarding torsion and its redistribution back in the 80s. I would suggest you look for that paper.