Ditto metengr's comments, you need a proper welding engineer (I am currently available, nudge wink). Even then, many WEs have no experience fabricating such heavy plate (this sounds like it is a reactor vessel, possibly for refinery). One thing is for sure, do not skimp on weld consumable quality, and scan the tech spec fine print for requirements that are over and above Code. The quality, capability, and experience of the fabricator are vital to success.
One pitfall will be this: the standard 1/8 inch depth specified for back cladding (to match SS321) will NOT be sufficient to achieve equivalent corrosion resistance. Draftsmen seem not to know this, having copied this dimension from one drawing to the next ever since Moses. Unless you have a well controlled, low-dilution two-layer WPS, you will need to allow room for three layers of weld if you plan to avoid corrosion. Three layers will necessitate almost 1/4 inch depth of preparation. Otherwise, in grinding flush with the surrounding base metal, you will grind down into the second layer and possibly even the first (buttering) layer. In any event, welding a large project like this requires something automated and specialized for the task (for both the groove welds and the cladding).
I have butted heads with several WEs over the cladding question, but I have observed many shell courses for SS clad polymer reactors that developed internal rust strips just from sitting out in the weather.
Good luck.