Dougt115-
Ti and Al are a poor galvanic match, so galvanic corrosion might be something to consider. A metal filled epoxy is not the best choice for sealing a thread interface. It would be better to use a sealant material that remains flexible when cured.
Your description of how the bolt is loaded was unclear. Is the bolt itself actually subject to cyclic bending loads? Or is the bolt securing a component that is subject to bending moments? A bending moment applied to a bolt threaded into a tapped hole is a bad situation, since there is a big stress concentration created at the root fillet of the bolt thread pitch just before the start of the tapped hole threads. Normally you try to avoid putting the threaded portion of a bolt in shear or bending.
It would also be worthwhile to evaluate coatings for the threads to prevent galling. If the threads begin to gall/seize at installation and you're only relying on wrenching torque to determine preload, it would be quite easy to install the bolt without any clamping force created on the component being attached.