beaerohead,
Here's what I have observed:
The part in question is a metric part, with a threaded hole, 1/4-20 UNC, created using the 'new' Hole function.
Option 1: Create Metric drawing of the metric part, then use "Feature Parameters" to create an annotation (selecting the 2nd Threaded Hole feature corresponding to the actual threaded hole, not just the thru drill). The annotation reads "M 6.4". Looking at the Template drop down menu in the "Feature Parameters" block, one can see that only "ansi_mm", "iso_din", and "jis" are selectable; "ansi" is greyed out.
Option 2: Create Inch drawing of metric part. "Feature Parameters" results in successful annotation "1/4-20 UNC-2B". (Actually there's an issue in that the depth is falsely reported as a value when it should read THRU, but that is another matter...) As a note, the Template drop-down menu now has only "ansi" as the selectable option; the others are greyed out now.
So, unless there is a setting where I can enable "ansi" templates inside a metric drawing, and the other templates inside an inch drawing, then it would seem that the problem exists as I've described it in the above post.
Where's that setting?...