Things you need to do:
1. You need to come up with a free-body-diagram to solve for the weight distribution (which will include finding the CG). If parts can move, you may have to consider several different orientations. You may also need to think about other possible loads on your parts.
2. Determine exactly what material you will be using and what it's properties and capabilities are - then knock the capabilities down at least by half (you should probably have an even larger factor of safety for something like this - it looks like something that might end up being beat to crud)
3. Once you know the weight distribution and the material specifications, you'll have to look at buckling and yielding in your structure for your worst case load condition. If there's any question about which case is the worst case, you should calculate it for all the cases that look like they might be the worst. Pay special attention to stress concentrations in areas such as holes, fillets, and larges changes in net section. Welds are an area of special concern because the material properties of a weld are often lower than that of the parent material. In addition, welds are often at the same locations as stress concentrations. Check literature for information on analyzing weld joints (Shigley's Mechanical Engineering Design is good for basic analyses)
4. You'll have to determine what an acceptable deflection for your part is and make sure the cross section of your supports. You should calculate the deflection your parts under worst case loading. If there's any question about what is the worst case, calculate all cases in question.
5. If your structure fails to meet your requirements in any of the calculations you performed, change your geometry (or material) and iterate until you have a design that works.
If you don't have experience with the types of analysis that I mentioned above, you may need to go get outside help. It looks like you're dealing with some pretty heavy parts, and that a failure could end up hurting someone. You could always try your own hand at an analysis, then hire a consultant to check your work.