Yes, steam turbines which exhaust to air cooled condensers ( instead of using wet cooling towers for cold circ water) must operate at both backpressure and vacuum depending on ambient conditions. The change in backpressure affects the exhaust loss and also affects the energy produsced by the last 2 rows of blades.
If the exhaust drops to too low a pressure ( hi vacuum) and the steam exhaust velocity approaches 50% of sound speed, then aerodynamic instability or "flutter" occurs and the blades vibrate and eventually can fail. Also, at too low a pressure, the last 2 rows behave as compressors instead of turbine blades and cause the steam to heat up. If the exhasut overheats, it will also cause the blades to contact the casing and damage ensues.