Steam flow to clean in place

[pardal]

Hi all , there is a method to get the steam flow need to clean in place and sterlizate a given volumen at a vessel ?
It is a 85 litre free volumen.

The temperature to reach shall be 121 °C.

I have to determinate the flow and pressure of the Clean Steam Generator.




Pardal

 

[quark]

It depends upon whether or not you require overkill approach. As a universal rule of thumb, 30Kgs of steam is considered for 1000 Liters (or 1 M³) volume. This for a sterilization time of 20 Minutes. So your flow rate will be 90Kgs/Hr. Generally you can get the temperature of 121⁰C at 2.1 Kg/Cm² abs. but generally 2.5Kg/Cm² abs. is used.

If your sterilizing temperature is 135⁰C, the sterilization time becomes 3 Minutes.

For steam sterilizers, total flow rate of 2.5Kgs/Hr is used for a volume of 27Liters at full loaded condition and the flow rate for chamber and jacket is 60% and 40% respectively.(The only proof is that I have my thumb well in place)

Note: Steam pressures can be obtained from steam tables.

Regards,

 

[pardal]

I Quark:
Thanks for yours tips.
Could you submit to any other places or links to get more info.
Where I can get steam in place specifications.?
The use is for pharmaceutical industrie.
Thanks againg.




Pardal

 

[quark]

Sartorius mastered this application. Check the website

http://www.sartorius.com.

If any of your colleagues is an ISPE (Internatinal Soceity for Pharmaceutical Engineers) member you will get ton loads of information (some are for free too)

Regards,