If it leaks, what happens? Do you lose some inert material, or do people die?
If the latter, you can't use threads.
If the former, it's a matter of finding a thread sealant which will handle the thermal cycling from room temperature to -100 C. You'd need to speak to the sealant manufacturers to be sure. However, if you're going to be relying on just teflon tape, experience shows that teflon tape alone isn't a particularly robust solution for joints subjected to repeated, steep thermal cycles.
Liquid metal (i.e. seal welding) is a very reliable thread sealant...