In general detonation starts far away from the plug and in hot areas, so putting the plug near the hot exhaust valve, but in a location with a good combustible mix seems like a good spot.
Dual plugs should be widely disbursed to make all parts of the chamber close to a plug. Mechanically difficult.
The Harley K model was a pretty highly (factory and aftermarket) developed air cooled flat head engine. Supposed during displacement tech inspection or protest tear downs the factory mechanics or riders would take the cylinder heads, wrap them in shop rags and sit on them to keep them from prying eyes.
Here is a modern (dual plug) version.
head
Note the block is also "relieved" to take part in mixture flow or whatever.
Are you allowed to modify ("relieve") the block too?
The Beach Boys were singing about it in 1963.
"She's ported and relieved and she's stroked and bored.
She'll do a hundred and forty on the top end floored
She's my little deuce coupe
You don't know what I got"
In one of Andy Granettelli's books he claimed he more-or-less invented "relieving" flat head Ford blocks for high performance, and that the factory started including that feature. Of course he also "designed the Chrysler 300 engine."
With the mile-long combustion chamber it seems physically tough getting a high compression ratio. And the long chamber brings along a related propensity to detonation even when inoculated with multiple spark plugs.
These guys, (and air cooled BMW specialists) advocate dual plugs for engines with far more more compact combustion chambers than yours.