By definition, detonation is when the flame fronts or propagation of a chemical reaction through the medium is faster than sonic velocities...causing unusually fast increases in temperature and pressure. I haven't done any work with Internal Combustion Engines in a while but I think that in the case of combustion, you get a relatively gradual increase in pressure while the piston begins moving past TDC, allowing a little expansion as the gases continue to combust. With detonation, almost all of the combustion happens right at TDC, greatly increasing the overall temperature and pressure inside the combustion chamber for a short time, putting greater cyclic stresses on all associated pressure boundaries, as well as exposing them to higher temperatures. In the case of multiple flame fronts you aren't quite detonating but you are at least doubling the combustion rate, thus halving total combustion duration, causing the same issues that combustion causes.
Also, just thinking about the propagation of multiple flame fronts, I wonder if there could be some constructive interference going on where the two fronts meet, I guess from a transient standpoint you could have a line around the edge of the combustion chamber where the 2 flame fronts collide and the pressure wave associated with each one constructively interferes to cause uneven and extreme loading along that line...just thinking outside the box, feel free to correct anything that could not or would not happen ^_^
peace,
LostHippie