Find, Follow, and, even better, work to understand the AACHEN guidelines. (Only use the design details labelled good, not the ones called bad or even acceptable).
Mid 90s FORD Europe (Lima?) received a batch of new spindles for an engine component machining tranfer line. FORD, against the spindle manufacturer's vigorous protestations, had specified the then-current spindle version of INxxO seals. Shortly after the line was commisoned spindles started failing. Each time the spindle manufacturer claimed coolant contamination had been the cause. After many coolant contamination bearing failures, and receiving the report from the spindle manufacturer's in-house testing, FORD payed the spindle manufacturer to substiture their own proprietary labyrinth with AIR purge (which is what the spindles would have been built with). The spindle failures stopped.
The coolant environment on machining transfer lines of the time was EXTREME. Coolant sprayed everywhere inside an enclosure where the workpieces, tooling, (and spindle noses) lived.
As of about 3 years ago I believe at least one of the INPRO designs for spindles included, (if not relied on) a certain amount of AIR purge, probably along with their belov-ed vapor blocking flying o-ring.
Please don't get me wrong. I am sure bearing isolators have their place.
I checked out the INPRO performance gurantee.
It is signed by Mr David Orlwoski, the inventor and patenter of bearing isolators.
"If you are not satisfied that it is working to your satisfaction, Inpro will either modify the Isolator to your satisfaction or refund your purchase price. "
They promise, by golly, to keep re-designing that isolator until it actually works, or maybe you will just get the isolator price back.
Each Machine tool Spindle rebuild cost several 1000s of $ (American bucks). Machine tool spindles are typically sold with a 1 year warrantee. Defective bearing, ineffective seal, poor workmanship or flawed materials, the spindle maker gets to eat it all, for a year.
Several years ago an acquaintance who builds race engines professionally had a valve spring retainer fail, and a valve wandered into areas it did not belong. Many expensive parts were destroyed. The manufacturer of the cam/lifter/valve/ spring/retainer system paid to fix the engine. I don't think many companies did that then, and fewer would today.
As of about 3 years ago The SETCO seal included a fully developed (by design and verified with tests) AIR purge with carefully managed AIR delivery.
Air, air, air.
If I suspect something is going to try to get into my spindle bearings I'd include some air purge.