I've looked over several alternatives to reduce fouling in seawater systems on marine vessels the past two years. These have been for both copper-nickel and non-copper nickel systems.
Generally, there are two opposing issues that apply to most treatment type systems:
1. Is the system sufficiently toxic to significantly reduce fouling?
2. Is the system sufficiently benign and legal from an environmental perspective?
Those points stated, I consider chlorination systems to be effective and easily installed. UV and ozone systems may or may not be effective, depending on local conditions. Copper systems (specifically the copper anode sytems in which a DC current is used to force the dissolution of a copper anode) usually do not deliver sufficient amounts of copper the be effective.
There are also automatic cleaning systems that can be used on tube-and-shell heat exchangers while the system is on-line. These do nothing, however, for the piping to and from the heat exchangers.
I don't believe coatings of any sort will be effective for long periods of time (i.e. years). Antifouling coatings work by using toxins (such as copper), and the coating must make available sufficient toxin to control fouling, but must also contain sufficient toxin to provide the desired service life.