Nate101,
For cycle time on a multi-spindle, we used the cycle time which equals the longest step. For single spindle, we used the time from one part hitting the pan to the next regardless of the number of steps.
I never set up a CNC so cannot comment on them.
As a rough rule of thumb one could say that the smaller, simpler the part, the smaller the run needed to justify a screw machine. However, a screw machine shop needs a bunch of such jobs to keep operating. We ran jobs as small as 100 pieces on relatively simple parts but they were justified because the cycle time was much shorter than if we had run them on an NC machine or CNC turn center. We also had capacity to fill.
The more involved the part, the longer it will take to set up and the more tooling/attachments will be needed. Special forms will take special tools and requires that the shop have toolmakers with slightly different skills than a CNC turning shop. One tool on a CNC can generate many different features where a screw machine may require several tools or a custom configured tool.
My experience was that it was generally easier for a SM operator to transition to CNC than vice versa.
Hope this helps some.
Griffy