When we pressurize rooms for pharma, we use:
Airflow Through Large Intentional Openings
The relationship describing the airflow through a large intentional opening is based on the Bernoulli equation with steady, incompressible flow. The general form that includes stack, wind,
and mechanical ventilation pressures across the opening is
Q = 776*C*A * SQRT(2* delta-p / density
(This is equation 36 in Ch 16 of 2013 Ashrae Fundamentals in English units)
where:
Q = airflow rate, cfm
C = discharge coefficient for opening, dimensionless (usually 1.0 for a door)
A = cross-sectional area of opening, ft2 (Single door with 1/4 crack, = 0.23 ft^2)
p = air density, lbm/ft3 (0.075)
dp = pressure difference across opening, in. of water (convert 15 pascals to English)
776 = unit conversion factor
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