Clients normally don't set exact figures for negative pressure, but only specify that they need it.
Consider that building tightness directly affects the issue, so exact selection that takes into account only ventilation system does not help.
Normally, you should, for instance, specify exhaust fan with 5% more flow than supply fan.
There are some processes that does require exact control of negative pressure. Than pressure sensor-regulated fan is needed.
The issue of room volume change I do not completely understand.
If there are some partitions occasionally used, you will have to know which volume combinations may exist, so to select adequate fans that cover range, as pressure situation will certainly change.