George,
I haven't really experienced noise issues by increasing the allowable pressure drop. There are other "rules of thumb" regarding duct velocity limits. For instance, for office buildings, the recommended duct velocity is 2200 fpm for main rectangular ducts, 2400 fpm for round (with maximums of 2500 and 3200 respectively) and 1600 fpm rectangular branch ducts, 2000 round branch ducts (with maximums of 2000 and 2500 respectivley), also for office buildings.
According to my Ductulator..."these velocities generally produce sound levels within the occupies spaces that are considered acceptably quiet...the maximum velocities should be observed when the duct size must be reduced to pass through a space restricted area."
If you "play with" the Ductulator, you'll see that if you select ducts based on these velocity limits, you will get 2-3 times as much airflow through a given duct as you would selecting at the starting friction point (e.g., 0.1/100' for supply air). You will also of course quadrouple (or some other amount) your pressure drop. The point is, you have a pressure drop starting point and the "end" point should be based on velocity limitations. Then of course you should make sure your motor hp/esp doesn't get astronomically large.
It's analagous to pipe size selection. You should select sizes around 4ft/100' head loss for optimum economic design (hp vs noise), which will result in modest velocities (4 fps or so); but you can go up to 8 fps for 8" and smaller piping and 9 or 10 fps for 10" and larger piping.