From long ago with truck lug nuts:
Use the 1" impact wrench (normal tool for the job).
If that doesn't work, tap on the side of the socket with a sledghammer while using the impact wrench.
If that doesn't work, use tire tool + cheater pipe.
If that doesn't work, use tire too + cheater pipe + tap on the socket with the sledgehammer.
If that doesn't work, heat the nut up with a torch and start running through the previous steps. At some point, something will move.
You specify "hold down" bolts. Does that mean anchor bolts?
If so, my concern would be twisting the bolt off at some point below the nut. And in that case, the nut splitter might be the first tool to try.
Also, with an anchor bolt terminated in a nut, I have wondered how hard it is to twist that bolt out of the embedded nut. Impossible? Happens every time? Rare but can happen? I dunno.