This is a first guess, but it sounds to me like the Windows registry entries for AutoCAD are missing or have bad pointers. The more unrelated programs that have been installed since AutoCAD, the more likely this is. That situation can be fixed by uninstalling and re-installing of AutoCAD. Win 7 has been remarkable stable for me, so I'd not suspect the operating system other than goof-ups in the registry.
That's only an opinion, of course. I can't check your machine from here. It seems that I remember AutoCAD storing a lot of user settings in the user's appdata folder. Windows or AutoCAD itself may not know where to look.
Other items that come to mind:
Security settings on the folder containing your stored plot configuration may have changed. Windows Update has been known to do this.
If your AutoCAD is an older version, it may need to be run under compatibility settins for Win XP. Sometimes programs run for many months before that becomes an issue.
Popping AutoCAD out and back in again is a bit of a hassle, I know. That's where I would start if it happened to me, though.
You might wait around and see if another eng-tipper has specific knowledge of your issue.
Best to you,
Goober Dave
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