The Mustang guys had it a bit easier than what you have ahead of you, as that car's IRS was designed to fit up to the same points as the stick axle that was concurrently offered.
I doubt that your car has adequate strength where you'll want the upper link(s)* to attach, and adding only local panel stiffening around any additional brackets may not be enough either. It wouldn't hurt to 'overbuild' a bit here for stiffness as well as for strength, as you may find you have wheel hop under either hard acceleration or hard braking where there would be some sort of impact factor involved. At least the few extra lbs would be more or less over the "right" wheels.
* Depending on what you're going to do with the car, you may want to consider a torque arm suspension (a la GM's 3rd/4th gen F-body and a fairly common retrofit to the Fox Mustangs) or a 3-link (as in the latest S197 Mustangs and also a retrofit for the Fox/SN95 axle, and I suspect is also used in Greg's supercars and sedan) instead of the triangulated 4-link.
Norm