To be honest, there will be no pump damange, but there will be seal damange. The seal has springs that hold the seal faces together. This tensions is adjusted based on the pressure differential across the seal and the size of the seal faces (i.e. the seal application) to ensure that proper fluid lubrication exists between the seal faces.
If the pressure on the exterior of a plan 53 is lost, then the only thinkg holding the seal faces together are the springs in the seal, itslef. I would think that you would see seal failure rather quickly (depending on the pressure differential).
GHartmann is correct when he says that you need to consider the containment issues. The plan 53 was selected (probably) to limit exposure of the liquid to the atmosphere (because the whole idea is that nitrogen is pushed into the process when a seal fails, as opposed to process fluid being push to atmosphere when a seal fails).