I agree with both previous answers. Running at end of curve comes with a reliability penalty. If you want to quantify that penalty, there are a few details that you could consider. As previously mentioned, running well above the best efficiency point is not recommended. You may want to calculate how far out end of curve would take you. Divide the flow at end of curve by the BEP flow. If that is above 105%, you have reason for concern. If it above 120% you should expect a severe reliability penalty. Other concerns with end of curve operation in this application could include NPSH margin and submergence. You should evaluate the NPSH required at the higher flow rate as compared to the NPSH available. The lower the ratio of available over required, the lower the expected reliability. And even if the NPSH margin looks acceptable, you could still have a submergence problem. At the higher flow, you require a greater submergence to avoid the possibility of votexing and ingesting gas. At the higher flow rate, you have higher velocity. If there are any solids in the product, you could experience accelerated erosion. If you have corrosion mechanisms, they could be accelerated by the higher velocities and possible high temperatures because of the inefficiency. In short, there are a lot of ways this could hurt you.
Johnny Pellin