We use knife gates extensively in slurry services, and have had a number of issues getting them to close.
In some cases, the valves had origianlly been specified for pressure from one side only. This resulted in a valve ordered and installed with one way sealing, very little support for pressure on the gate form the non-pressure side. In actual fact during operation they received pressure from the non-pressure sode, and the gates bent, making them, difficult to close. You could check this by opening your valve fully and see if the gate has a bend in it.
In many cases we get rocks or sand build-up in the bottom of the valve. We have taken to installing the valve upside down, so that the seat stays clean. Not always possible to change in existing installations but should be thought about for new installs. We selected upside down over 90 degrees because the valves are actuated, and the actuator weight out the side would be too much bending on the yoke.
The idea from Ed to partially close and flush is good. This sometimes works.
Good luck