The PRV should be set at about 15% less than the max pressure rating of the critical equipment. Factor in the effect of the static head between the equipment & the relief valve. Discharge to a safe location with drain where relief valve discharge will be visible. If closed system, make sure the makup water pressure regulating valve is set for correct pressure such that when the system gets hot, the expansion tank volume will prevent the system pressure from exceding the system relief valve pressure, otherwize treated water will spill out the drain.