This is a very common situation here in NYC reducing the Con Ed steam from 200 down to 15 psig. About 95% of the installations use 2-stage reduction, because it is safer and it is a Con Ed regulation if there are no SRV's. There is NO PROBLEM mixing and matching the types of regulators used. We often replace one pneumatic in a series of two with a pilot operated with no problem, as long as the valves are sized correctly. Also, the rule is to keep the high pressure rating on the valve (and flange) up to and including the second PRV.
It is safe because if the first valve fails the second valve can handle the full pressure drop.