Thanks for the replies, let me clarify. The device is small (roughly 1" x 0.5" x 0.25"), single use only, medical device and has two chambers separated by a thin metallic membrane. I'm looking for a way to seal the two outer housings to each other and sandwiching the membrane between them. I am limited by size and materials since it is a medical device and the two chambers contain very different materials. One is a drug product that contains water, vegetable oil and a surfactant. The other chamber contains a propellant. By hermetic, I mean the device cannot lose more than 25% of its propellant mass over 18 months. I was thinking about over molding a PET or similar plastic over the housings, which are currently Ti in order to create the seal, I realize PET is not hermetic, but if I limit the area of exposure of PET to the propellant, I think I'll be okay. My question was, does anyone have similar experience and were they able to create a good enough bond between a metal and a plastic so that a gas (or liquid) couldn't find a fluid path through the interface. I can't really use an o-ring or seal without compromising the size constraint I have. Hopefully that clarifies my question.