I worked with Prof. Hofbauer several years ago, although not in any direct project-related capacity.
I would agree with some of tbuelna's criticisms of the opoc engine regarding the need for a scavenging supercharger; lubrication of ported cylinder liners; less than optimal combustion chamber shape and side-mounted injectors.
What the engine gains in an extra 2 sets of conrods and bearing shells per piston pair it saves in the lack of cylinder heads, with all their associated pieces: camshafts (4 in total for a DOHC HO engine), lifters, valves, springs, etc. (4 of each per cylinder for a contemporary engine). What it does for the overall BOM parts count, think about it...
The packaging in a transverse automobile layout is granted but a moot point as evolutions of the engine have been directed specifically toward trucks, aviation, military and APU applications.
As for the power density being a result of a high BMEP with attendant rough and noisy running, I disagree. I don't expect torsionals and combustion noise to be any higher than contemporary Diesel engines of the same cylinder count and using the same FIE/combustion development technology. The high power density comes about since this a 2-stroke engine, meaning that for the same displacement, RPM and power output as a 4-stroker, you need half the BMEP, or put another way, for the same displacement, RPM and BMEP, you get double the power. Yes, 2-strokes have different major critical orders than 4-strokes, but dealing with them are no different than other successful 2-strokes.
I agree that BSFC is indeterminate; what FMEP is reduced from the lack of valvetrain losses is countered by the added friction of two extra set of conrod small-end bushings
and big-end bearings per piston pair, plus small pistons in relation to the swept volume. On balance I'd say BSFC would be a wash compared to contemporary Diesel engines.
The opoc layout is inherently balanced (though not absolutely completely as claimed, since the L/R ratios of the two length conrods and therefore motion profiles of the inboard and outboard pistons are slightly different. This is however, still better than either inline- and conventional boxer 4-cylinder layouts, the latter of which must still put up with a small yawing moment due to the cylinder centerline offset.
I have no affiliation with the opoc engine or its development company, and I don't believe I have biased what I've said above. Rather, I believe it's a balanced critique based on what is known of the engine with objective engine engineering principles applied.
On a similar note, although not an OP engine in the strict sense of the term, I've seen an BMW boxer engine using an uncoventional cranktrain mechanism referenced in US Patent 5,785,029 that interests me.