You can allocate a com port number in device manager. Open the com port properties and set it up in resources, untick use automatic settings. You may have to restart your computer.
USB to serial converters can be a pain but a lot depends on your computer hardware. I have an HP and a lot of converters do not work properly. The Omron one does.
If you have RSLinks, make sure you set it up to start as a service. It plays merry hell with lots of software. If you have used it, restart your computer before using anything else.
Some software will also grab an internal modem as a com port. Disable the internal modem and all is well.