makoy888....
I took a look at your model, ran it, played with it, and exported the .net file to review. Here are my observations. This is not a complete critique of the model, but I think there is more than enough here to get you started and maybe even enough to get you finished. Please ask again if you have additional questions.
GAPS
[ol 1]
[li]The pipes and nodes N/NW/W of and served by SiladReservoir are not connected to the rest of the system. I suspect there should be something* connecting Node i-107 and Node n-106.[/li]
[li]The pipes and nodes SW of and served by MangaReservoir are not connected to the rest of the system. I suspect there should be something* connecting the tank or Node 107 to Node 62A and/or Node 62. Downstream of MangaReservoir is another gap at AlibaughReservoir. Here, I suspect there should be something* connecting the tank or Node i-124 to Node n-123.[/li]
[li]Immediately S of PoblancionReservoirs are two gaps, one between Node 103 and Node 53 and one between Node 97 and Node 88. I suspect there should be something* closing these gaps.[/li]
[/ol]
As you can see, there is a pattern here. When I look at each tank, I see one or two gaps in the system and I am pretty sure they should not be there. Also, your Water Treatment Plant is not connected to the system. What this means is that each disconnected part of the system is operating independently and no water is moving between them. I suspect that is probably not the actual case.
BTW, I inserted fictitious pipes in all 16 gaps (1m long, 25mm diameter, C=140) and got the model to run without generating any error messages. Most of the pressure problems are still there, but at least the model runs.
* That "something" might be:
[ul]
[li]A pipe, if the isolated tank is supposed to float on the main part of the system.[/li]
[li]A pump, if the isolated tank is higher than the main part of the system.[/li]
[li]A pressure reducing valve or pressure sustaining valve, if the isolated tank is lower than the main part of the system.[/li]
[li]Duct Tape, if all else fails.

[/li]
[/ul]
TANKS
At first glance, the tank elevations seem to be OK with respect to their service areas. The tanks are pretty small from my experience. However, if they really are small and are modeled correctly, then this is just an observation, not a critique of the model. BTW, if the Water Treatment Plant puts out a fixed or nearly fixed HGL (e.g. from variable speed pumps or gravity feed from the clearwell), then I would model it as a reservoir.
PIPES
[ol 1]
[li]I only looked at the first time step (T = 0:00 hrs). I noticed that some pipes are closed (e.g. Pipe 150, Pipe 152, Pipe 159, etc.). Should these pipes be closed? For example, Pipe 150 has an initial status of OPEN, but the first time slice has it CLOSED. I didn't find any controls or check valve that caused this, so it must be something else that I didn't find yet.[/li]
[li]The pipes are relatively small (50mm to 200mm). But, like the tanks, if they really are that small, then this is just an observation. At T = 0:00 most of the flow velocities are very low. I didn't check at the other timesteps.[/li]
[/ol]
NODES
[ol 1]
[li]I only looked at the first time step (T = 0:00 hrs). Most of the pressures looked normal to slightly high. I would expect the need for pressure regulators at some buildings to protect the plumbing and fixtures inside. The plumbing code I use here in California requires building pressure regulators for pressures exceeding 80 psi, or 56 meters.[/li]
[li]However, check the pressures at the following nodes: Well, i-104, i-124, 97, 103, 104, i-107, and 109. These nodes have pressure heads that are many times the Earth-Moon distance. Seriously. The biggest number I found was at Node 109: 2.18x10^7 m, which is nearly 57x the Earth-Moon distance. This is either magic or an error.

This appears to be related to the gaps and closed pipe in the system, since each of these nodes is next to a gap and/or has a closed pipe attached. Fix the gaps, open the closed pipes, and I suspect these high pressure heads go away.[/li]
[/ol]
CONTROLS
[ol 1]
[li]I don't see any controls. Should there be any? If there are any pumps that fill higher tanks or PRVs or PSVs that prevent lower tanks from overfilling, then there should be something.[/li]
[/ol]
PATTERNS
[ol 1]
[li]Pattern 1 looks like a reasonable diurnal curve.[/li]
[li]Pattern 2 is just straight 1's, which would be correct for fixed inflows and/or demands.[/li]
[li]Most nodes have Pattern 1, which makes sense.[/li]
[li]I don't see anything in the model that resembles a fire flow. I typically do static and extended period models, and haven't done a water quality model in years. The EPS is useful for modeling how tank levels fluctuate, and that is a legitimate purpose here. However, for a system this size, the fire flow is likely to be the biggest stress on the system. For fire flow, I suggest creating a second EPS, but this time with fixed HGLs in the tanks and use the timesteps to move the fire flow around the system (here, time is irrelevant). When I do a static model with fire flows, I typically make the first time step the Average Daily Demand (this is mostly for debugging the model), make the second time step the Peak Hour Demand, and make all additional time step Maximum Day Demand Plus Fire Flow. I set up fire flow demands at the critical nodes throughout the system then turn them on and off one at a time at each time step. If you search for my recent posts, I covered this a couple times for other Eng-Tips members.[/li]
[/ol]
REACTIONS
It doesn't appear to me that you are modeling water quality, so why (under TIMES) do you have the Quality Timestep set at 0:05, but the rest of the model is based on a Hydraulic Timestep of 1:00? If you are only modeling hydraulics, and a timestep of 1:00 is sufficient for that purpose, then I suggest changing the Quality Timestep to 1:00 as well. This will reduce the total number of iterations EPANET has to calculate and will save you time because this model actually a bit of time to completely run.
I hope this helps.
Fred
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"Is it the only lesson of history that mankind is unteachable?"
--Winston S. Churchill