TomBarsh has given the "correct" answer. If you want the "practical" answer, here it is: assuming that the connections to these new holes are of a nature that do not transfer significant moments to the flange, and the total area of the three holes is no larger than the area of the single hole permitted in an ordinary blind flange per B16.5, you're OK in practical terms. The openings must be spaced properly to permit the attachment welds (if those are necessary) to be done properly.
If the total area exceeds that permitted for a single hole in a blind flange, you need a hubbed blind (good luck finding one!) and you probably should do an Appendix 2 calculation per ASME VIII-1. The blind flange (in fact even the hubbed blind) will probably fail per Appendix 2 because ASME B16.5 flanges are over-bolted, but you will need to add thickness (i.e. to make a custom flange) or increase the flange class if you go the Appendix 2 route.