The primary difference in centrifugal chiller design is the choice of motor drive: open vs. semi-hermetic, and refrigerant: low pressure vs. high-pressure. Both decisions impact lubrication issues, noise, efficiencies, and reliability.
The 6" diameter and 20,000 rpm impeller is no cause for concern itself. Rather, it is a measure of the ratio between volume and pressure dictated by the refrigerant (higher pressure). The McQuay centrifugal compressor design is essentially the same Westinghouse design invented 50+ years ago. Even so, there is no inherent advantage/disadvantage with the compressor that outweighs all others. There are preferences.
As for the oil pump/reservoir system changes, or other issues ... well - you saw my previous comments.
The attributes of that chiller design compared with Carrier's newer R-134a designs, Trane's low-pressure R-123 designs, or York's open-drives are too numerous and complicated to discuss on a forum format.