I think C.Montgomery Burns (old bald dude in The Simpsons) said it best,
" Friends, family, religion, these are the three demons you must eliminate to be successful."
My own personal reflection on this;
1) Friends, need em, need plenty of friends and/or contacts to get ahead in life. However the restraint required not to smack them can be enormous sometimes.
2) Family, need em, who else will put up with your nonsense when you complain, and who else will you train to take over the world, or at least start a whole mess of problems. However they also sap your energy, but the investment is worth it for world domination.
3) Religion, that can go, I don't like to rely on inanimate things to help me out, and I have a clear conscience, well very little conscience anyway.