In most cases you should be able to trim a Francis Vane impeller, though there may be something about a particular design preventing it - for instance the material may prevent machining, like a 28% chrome cast iron. There's also usually less range of hydraulic coverage by impeller trim on a francis vane than a purely radial.
As for the affinity laws, they're still classified as radial flow impellers with specific speeds below 4000, so they could generally follow the laws. While they should be pretty accurate for speed changes, I don't think I'd trust them for impeller trim changes. Depending on the specific speed, the vane geometry can change pretty dramatically as you trim down the outer diameter, which becomes more prominent the closer you get to 4000 specific speed.