baja,
I am assuming you talking about modifying an aircraft that is already FAA type certificated. You do not need OEM permission, you need FAA approval. The following is from 14 C.F.R. 1.1 definitions:
Major alteration means an alteration not listed in the aircraft, aircraft engine, or propeller specifications--
(1) That might appreciably affect weight, balance, structural strength, performance, powerplant operation, flight characteristics, or other qualities affecting airworthiness; or
(2) That is not done according to accepted practices or cannot be done by elementary operations.
Minor alteration means an alteration other than a major alteration.
For more detailed information try the following link to an FAA website:
There are some grey areas and individual interpretation on whether an alteration is major/minor. A simple approach would be to speak with your local FAA FSDO (Flight Standards District Office)and discuss your modification. If your modification is simple, you/your company can normally put together a data package that is acceptable to the FAA. More complicated alterations can require substantial amounts of data. That is where a helpful OEM can/might provide data that the FAA will most likely accept as part of your data package. A DER can also be used to supply data that the FAA can choose to accept.
And of course in order to be allowed by the FAA to alter an aircraft you have to be an FAA certified repair station, airframe/powerplant mechanic or manufacturer depending on the type of alteration you are performing.
Good luck,
jstolp