For starters, look at stopping sight distance to the proposed crossing, walking distance to and from the nearest controlled intersections, traffic volumes and AADT, etc. You are investigating whether the midblock crossing would be safer than an intersection crossing. Another reason for a mid-block crossing is the block is too long to expect people to walk to the intersection and back.
In-pavement or overhead lighting is a supplement to standard signing and striping, not a replacement.
I suggest you read C. Zegeer's study on safety of marked vs unmarked crosswalks (available somewhere on the FHWA site). He concluded that markings alone do not make crosswalks safer. Also, at higher AADT's, marked crossings are associated with higher risk to pedestrians than unmarked crosswalks. Signs, in-pavement or overhead flashing lights, and raised median refuges are devices used to make crosswalks safer.
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