Dlrn78:
Generally, you will do as much or more to improve fatigue life by paying particular attention to surface finish and its orientation, lowering the stress range by reducing bending moment/stress and shear stresses; although there is some correlation btwn. fatigue life and Fy and Fu. Also, pay particular attention to any stress raisers such key ways, press fits, changes in shaft shape (dia.), and size and shape of transition fillets, etc. to name a few. A sketch with loads and dimensions would help get you better answers, and if there is welding involved, on any shaft, it’s a whole new design problem.