By my humble knowing the answer is no, if you have a valid NX license then you can execute GRIP programs. Unless the program is trying to make changes to your system folders (unlikely) it should be no problem.
Best regards,
Michäël.
NX4.0.4.2 MP10 / TCE 9.1.3.8_build_0711 / NX6.0.2.8 / NX7.0.0.9
Belgium