Interesting question. Obviously if some sort of "ring gasket" is chosen, there will be sort of an essentially open/exposed crack/aperture between the two flange faces from about the bolt holes outward. If a flat full-face gasket is chosen, the rubber say from near the bolt holes outward will at least not be compressed in the fashion of the rubber in the inner annular machined face-to-face/bearing area. If a special sealing gasket design is chosen, I would think it would be best if said special sealing mechanism/bulb etc. falls securely in that machined face-to-face area. I believe many years ago when there was a preponderance of gray cast iron flanges, there was probably more of an incidence of essentially unsupported (not uniformly supported between the faces by gaskets) gray cast iron flanges being broken by high bolting loads. While I guess it is possible some "codes" attempt to control this to assure some more perfect mating in some highly controlled applications; however, from a practical matter at least in some other applications with all manner of pipe, fittings, valves, pumps, meters, manufactured to various standards etc. that someone might want to join out that are "out there", I suspect this sort of condition is VERY hard to totally avoid.
For such reasons, I know that some manufacturers in the water and wastewater industries (e.g. ACIPCO) went with all-ductile iron companion flanges decades ago (even though others insisted on selling and keeping gray cast iron companion flanges in some standards).
I would offer up that in general ductile iron and steel flanges will be much harder to break than say gray cast iron items, when subjected to adverse loading by bolts or otherwise. I also remember there was some additional guidance offered up in some manufacturers literature and at least ANSI/AWWA standards I think with regard to a sort of unsupported bolting (see under "Bolts and Gaskets" heading at
"Also, per the Appendix of AWWA C110 and C115, high-strength bolts should not be used when a gray iron flange is involved in the connection." I guess the rationale (that could conceivably also be of interest here or other situations) is that lower strength bolts might at least make a not-too-delicate contractor etc. to at least work a little harder to break the gray cast iron flanges!