Isolation valves are generally not designed with flow coefficients that make them particularly good at controlling flow. Consequently, you don't have very smooth or accurate control and you could easily end up with a situation where the control system is not able to find a stable operating point and bounces back and forth opening the valve too much, closing the valve too much, etc.
Other than that, you will likely cause damage to the valve thus negating it's effectiveness for isolation as mentioned by TenPenny.
Generally, just not a good idea but it would really help to know specifically what type of valve you are talking about (gate, ball, butterfly, etc.).