Well, you basically treat it the same as a rectangular or T beam - same principles apply. For simple span cases, in fact, the inverted beams compression area is simply the top portion of the beam as in a rectangular beam. The lower area, with the "L" or the "T" flanges, are in tension so this really doesn't enter into your calculations for a simply supported beam. You can spread out your tensile reinforcing in the full width of the flange.
For a continuous beam of this type, at the support the lower portions of the beam are in compression and you treat it just like a normal "T" beam (its just upside down). But all the same design principles for designing "T" beams apply.