A microstrip of 0.3mm (.012 mil) is no problem on FR-4 for in a general use RF design (I assume you are on FR-4). Actual width may depend even upon how old the gerber photoplotter your board vendor uses, and how consist his process is from run to run.
Other factors for FR-4 (which I assue you are using) are dielectric variations lot-to-lot, the actual frequency of the signal (dielectric varies slightly with frequency), actual weight of the copper (copper thickness) and the prepreg glass content of a multilayer board.
Assuming your 0.3mm is on a multilayer (would have to be if it's 50 Ohm) the required width may vary with how much the copper is pressed in the prepreg in the lamination phase, which then again is dependent upon the glass/resin ratio for the particular prepreg(s) used to obtain the desired thickness. Then again, dielectric constant can vary slightly from one FR-4 manufacturer to another
Then again, many of the forumulas used to calculate the width of a microstrip are only approximations, and they vary when compared against each other.
What I'm trying to get at is there are a lot of approximations in getting to a solution for impedance matched traces on a PC board. You get close and that's fine for 90% of all designs. Unless you are working on a Teflon substrate, and measuring afterwards with a network analyzer to adjust your design, what you end up with is only a approximation.